Global Genetic History of Homo sapiens

Current Biology, Volume 20, Issue 4
Special Review Issue

The journey started around 60 to 70 thousand years ago in Africa, where modern humans evolved more than 150 thousand years ago, and where human diversity is still the highest among all continents in terms of genetic variation and languages. From there, humans settled Europe and South Asia and reached Oceania. The Americas (apart from the remote Oceanian islands) were settled last.

The course and the extent of these first migrations remains evident in the genetic makeup of humans living today, but later migrations and the cultural practices that people carried with them—farming in particular—have also left their legacy. That legacy looks remarkably similar wherever farming spread, in Europe, Africa, and East Asia. Natural selection also left its mark: A review by Jonathan Pritchard of the University of Chicago examines evidence for the genetic basis of human adaptations and the extent to which differences among human populations in characteristics such as lactose tolerance have been selected for over evolutionary time.

Each of the reviews is packed with fascinating insights. For instance, a review by Mark Stoneking and Frederick Delfin at the Max Planck Institute for Evolutionary Anthropology tells of an early migration of modern humans from Africa along a southern route to East Asia. Europe is perhaps the best-studied continent in terms of archaeogenetics, writes Martin Richards of the University of Leeds and his colleagues, and includes what Richards refers to as five major episodes, including the repopulation of Northern Europe after the Late Glacial Maximum. In the case of the Americas, DNA evidence has confirmed the Asian origin of indigenous Americans and more precise estimates of when Native Americans emerged. Dennis O'Rourke and Jennifer Raff of the University of Utah note, however, that many questions about the date of the initial colonization of the Americas remain.

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